Nihilistic Software is heading Resistance: Burning Skies, and after that is released they will probably do a PSVita sequel, likely called Resistance: Burning Skies 2.
SCE Bend is doing Uncharted: Golden Abyss, and after that is released Naughty Dog will probably start Uncharted 4 and not tell us for two years and then release it three years from now. Then the PS4 will come out and Naughty dog will switch franchises again.
Insomniac's kissed Resistance goodbye so I guess its safe to say that Nihilistic will take over it with a handheld Burning Skies franchise and then finally make Resistance 4. Or for all we know, Resistance 4 could be a handheld exclusive.
What about Uncharted though? I doubt that Naughty Dog is going to keep it after a fourth game which will have a heavier focus on vehicle use [remember, its not racing unless its in the title, like Nascar]. So I'm guessing that Bend will develop maybe one or two more handheld after the Golden Abyss and take over the series and then plunge into hell like Naughty Dog's other franchises.
Lets take a look:
Traveller's Tales made The Wrath of Cortex, a reasonably fun game in its own standards. That's why nobody bought Twinsanity and then Activision canceled their third game which would have finally brought Crash back to his glory.
High Impact Games killed Jak and Daxter with the Lost Frontier and now Mass Media Inc is trying to revive them with a remake, but I think that after that, it'll plunge where Crash is today. On the verge of a massive revival and pulled back last minute.